Macromolecular Antiviral Agents against Zika, Ebola, SARS, and Other Pathogenic Viruses
Identifieur interne : 000E07 ( Main/Exploration ); précédent : 000E06; suivant : 000E08Macromolecular Antiviral Agents against Zika, Ebola, SARS, and Other Pathogenic Viruses
Auteurs : Franziska Schandock ; Camilla Frich Riber ; Annika Röcker ; Janis A. Müller ; Mirja Harms ; Paulina Gajda ; Kaja Zuwala ; Anna H. F. Andersen ; Kaja Borup L Vschall ; Martin Tolstrup ; Florian Kreppel ; Jan Münch ; Alexander N. ZelikinSource :
- Advanced Healthcare Materials [ 2192-2640 ] ; 2017.
Descripteurs français
- KwdFr :
- Animaux, Antiviraux (), Antiviraux (pharmacologie), Cellules HEK293, Cellules Vero, Ebolavirus (métabolisme), Humains, Maladies virales (anatomopathologie), Maladies virales (métabolisme), Maladies virales (traitement médicamenteux), Polymères (), Polymères (pharmacologie), Virus Zika (métabolisme), Virus du SRAS (métabolisme).
- MESH :
- anatomopathologie : Maladies virales.
- métabolisme : Ebolavirus, Maladies virales, Virus Zika, Virus du SRAS.
- pharmacologie : Antiviraux, Polymères.
- traitement médicamenteux : Maladies virales.
- Animaux, Antiviraux, Cellules HEK293, Cellules Vero, Humains, Polymères.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Chlorocebus aethiops, Ebolavirus (metabolism), HEK293 Cells, Humans, Polymers (chemistry), Polymers (pharmacology), SARS Virus (metabolism), Vero Cells, Virus Diseases (drug therapy), Virus Diseases (metabolism), Virus Diseases (pathology), Zika Virus (metabolism).
- MESH :
- chemical , chemistry : Antiviral Agents, Polymers.
- chemical , pharmacology : Antiviral Agents, Polymers.
- drug therapy : Virus Diseases.
- metabolism : Ebolavirus, SARS Virus, Virus Diseases, Zika Virus.
- pathology : Virus Diseases.
- Animals, Chlorocebus aethiops, HEK293 Cells, Humans, Vero Cells.
Abstract
Viral pathogens continue to constitute a heavy burden on healthcare and socioeconomic systems. Efforts to create antiviral drugs repeatedly lag behind the advent of pathogens and growing understanding is that broad‐spectrum antiviral agents will make strongest impact in future antiviral efforts. This work performs selection of synthetic polymers as novel broadly active agents and demonstrates activity of these polymers against Zika, Ebola, Lassa, Lyssa, Rabies, Marburg, Ebola, influenza, herpes simplex, and human immunodeficiency viruses. Results presented herein offer structure–activity relationships for these pathogens in terms of their susceptibility to inhibition by polymers, and for polymers in terms of their anionic charge and hydrophobicity that make up broad‐spectrum antiviral agents. The identified leads cannot be predicted based on prior data on polymer‐based antivirals and represent promising candidates for further development as preventive microbicides.
Url:
DOI: 10.1002/adhm.201700748
PubMed: 28945945
PubMed Central: 7161897
Affiliations:
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Le document en format XML
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Zelikin</name><affiliation><nlm:aff id="adhm201700748-aff-0002"></nlm:aff></affiliation><affiliation><nlm:aff id="adhm201700748-aff-0004"></nlm:aff></affiliation></author></analytic><series><title level="j">Advanced Healthcare Materials</title><idno type="ISSN">2192-2640</idno><idno type="eISSN">2192-2659</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (chemistry)</term><term>Antiviral Agents (pharmacology)</term><term>Chlorocebus aethiops</term><term>Ebolavirus (metabolism)</term><term>HEK293 Cells</term><term>Humans</term><term>Polymers (chemistry)</term><term>Polymers (pharmacology)</term><term>SARS Virus (metabolism)</term><term>Vero Cells</term><term>Virus Diseases (drug therapy)</term><term>Virus Diseases (metabolism)</term><term>Virus Diseases (pathology)</term><term>Zika Virus (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antiviraux ()</term><term>Antiviraux (pharmacologie)</term><term>Cellules HEK293</term><term>Cellules Vero</term><term>Ebolavirus (métabolisme)</term><term>Humains</term><term>Maladies virales (anatomopathologie)</term><term>Maladies virales (métabolisme)</term><term>Maladies virales (traitement médicamenteux)</term><term>Polymères ()</term><term>Polymères (pharmacologie)</term><term>Virus Zika (métabolisme)</term><term>Virus du SRAS (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antiviral Agents</term><term>Polymers</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Polymers</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Maladies virales</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Virus Diseases</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Ebolavirus</term><term>SARS Virus</term><term>Virus Diseases</term><term>Zika Virus</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Ebolavirus</term><term>Maladies virales</term><term>Virus Zika</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Virus Diseases</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term><term>Polymères</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Maladies virales</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chlorocebus aethiops</term><term>HEK293 Cells</term><term>Humans</term><term>Vero Cells</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Antiviraux</term><term>Cellules HEK293</term><term>Cellules Vero</term><term>Humains</term><term>Polymères</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>Viral pathogens continue to constitute a heavy burden on healthcare and socioeconomic systems. Efforts to create antiviral drugs repeatedly lag behind the advent of pathogens and growing understanding is that broad‐spectrum antiviral agents will make strongest impact in future antiviral efforts. This work performs selection of synthetic polymers as novel broadly active agents and demonstrates activity of these polymers against Zika, Ebola, Lassa, Lyssa, Rabies, Marburg, Ebola, influenza, herpes simplex, and human immunodeficiency viruses. Results presented herein offer structure–activity relationships for these pathogens in terms of their susceptibility to inhibition by polymers, and for polymers in terms of their anionic charge and hydrophobicity that make up broad‐spectrum antiviral agents. The identified leads cannot be predicted based on prior data on polymer‐based antivirals and represent promising candidates for further development as preventive microbicides.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Andersen, Anna H F" sort="Andersen, Anna H F" uniqKey="Andersen A" first="Anna H. F." last="Andersen">Anna H. F. Andersen</name><name sortKey="Gajda, Paulina" sort="Gajda, Paulina" uniqKey="Gajda P" first="Paulina" last="Gajda">Paulina Gajda</name><name sortKey="Harms, Mirja" sort="Harms, Mirja" uniqKey="Harms M" first="Mirja" last="Harms">Mirja Harms</name><name sortKey="Kreppel, Florian" sort="Kreppel, Florian" uniqKey="Kreppel F" first="Florian" last="Kreppel">Florian Kreppel</name><name sortKey="L Vschall, Kaja Borup" sort="L Vschall, Kaja Borup" uniqKey="L Vschall K" first="Kaja Borup" last="L Vschall">Kaja Borup L Vschall</name><name sortKey="Muller, Janis A" sort="Muller, Janis A" uniqKey="Muller J" first="Janis A." last="Müller">Janis A. Müller</name><name sortKey="Munch, Jan" sort="Munch, Jan" uniqKey="Munch J" first="Jan" last="Münch">Jan Münch</name><name sortKey="Riber, Camilla Frich" sort="Riber, Camilla Frich" uniqKey="Riber C" first="Camilla Frich" last="Riber">Camilla Frich Riber</name><name sortKey="Rocker, Annika" sort="Rocker, Annika" uniqKey="Rocker A" first="Annika" last="Röcker">Annika Röcker</name><name sortKey="Schandock, Franziska" sort="Schandock, Franziska" uniqKey="Schandock F" first="Franziska" last="Schandock">Franziska Schandock</name><name sortKey="Tolstrup, Martin" sort="Tolstrup, Martin" uniqKey="Tolstrup M" first="Martin" last="Tolstrup">Martin Tolstrup</name><name sortKey="Zelikin, Alexander N" sort="Zelikin, Alexander N" uniqKey="Zelikin A" first="Alexander N." last="Zelikin">Alexander N. Zelikin</name><name sortKey="Zuwala, Kaja" sort="Zuwala, Kaja" uniqKey="Zuwala K" first="Kaja" last="Zuwala">Kaja Zuwala</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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